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Adult acute respiratory distress syndrome

MedGen UID:
20540
•Concept ID:
C0035222
•
Disease or Syndrome
Synonyms: Adult Respiratory Distress Syndrome; Respiratory Distress Syndrome, Adult
SNOMED CT: Adult respiratory distress syndrome (67782005); Congestive atelectasis (67782005); DaNang lung (67782005); Vietnam lung (67782005); Shock lung (67782005); Acute respiratory distress syndrome (67782005); Adult hyaline membrane disease (67782005); Acquired respiratory distress syndrome (67782005); Pulmonary capillary leak syndrome (67782005); ARDS - Adult respiratory distress syndrome (67782005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0100130
Orphanet: ORPHA70578

Definition

A very severe form of acute pulmonary failure secondary to capillary permeability impairment. The symptoms include dyspnea, hypotension and multivisceral failure. The disease is characterized by bilateral pulmonary infiltrates and severe hypoxemia due to increased alveolar-capillary permeability. The severity depends on the degree of alveolar epithelial injury, with a mortality rate of 30-50%. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult acute respiratory distress syndrome

Professional guidelines

PubMed

Corticosteroids treatment for pediatric acute respiratory syndrome: A critical review.
Al-Sofyani KA
Saudi Med J 2023 May;44(5):440-449. doi: 10.15537/smj.2023.44.5.20220672. PMID: 37182909Free PMC Article
Controversies in the Management of Severe ARDS: Optimal Ventilator Management and Use of Rescue Therapies.
O'Gara B, Fan E, Talmor DS
Semin Respir Crit Care Med 2015 Dec;36(6):823-34. Epub 2015 Nov 23 doi: 10.1055/s-0035-1564889. PMID: 26595042
Treatment of acute (Adult) respiratory distress syndrome. The holy grail of surfactant therapy.
Taeusch HW
Biol Neonate 2000 May;77 Suppl 1:2-8. doi: 10.1159/000047050. PMID: 10828579

Recent clinical studies

Etiology

Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome.
Patel BM, Reilly JP, Bhalla AK, Smith LS, Khemani RG, Jones TK, Meyer NJ, Harhay MO, Yehya N
Am J Respir Crit Care Med 2024 Apr 1;209(7):871-878. doi: 10.1164/rccm.202310-1926OC. PMID: 38306669Free PMC Article
Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with extracorporeal membrane oxygenation.
Rozencwajg S, Pilcher D, Combes A, Schmidt M
Crit Care 2016 Dec 5;20(1):392. doi: 10.1186/s13054-016-1568-y. PMID: 27919283Free PMC Article
Pulmonary specific ancillary treatment for pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference.
Tamburro RF, Kneyber MC; Pediatric Acute Lung Injury Consensus Conference Group
Pediatr Crit Care Med 2015 Jun;16(5 Suppl 1):S61-72. doi: 10.1097/PCC.0000000000000434. PMID: 26035366
Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the Pediatric Acute Lung Injury Consensus Conference.
Khemani RG, Smith LS, Zimmerman JJ, Erickson S; Pediatric Acute Lung Injury Consensus Conference Group
Pediatr Crit Care Med 2015 Jun;16(5 Suppl 1):S23-40. doi: 10.1097/PCC.0000000000000432. PMID: 26035358
Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials.
Alhazzani W, Alshahrani M, Jaeschke R, Forel JM, Papazian L, Sevransky J, Meade MO
Crit Care 2013 Mar 11;17(2):R43. doi: 10.1186/cc12557. PMID: 23497608Free PMC Article

Diagnosis

Adult acute respiratory distress syndrome due to human parvovirus B19 infection after cardiac surgery: a case report.
Ma M, Ma X, Jia M, Hou X, Wang H
BMC Infect Dis 2022 Mar 7;22(1):231. doi: 10.1186/s12879-022-07213-9. PMID: 35255838Free PMC Article
Prediction of readiness to decannulation from venovenous extracorporeal membrane oxygenation.
Hartley EL, Sanderson B, Vasques F, Daly KJ, Lozinski M, Barrett NA, Camporota L
Perfusion 2020 May;35(1_suppl):57-64. doi: 10.1177/0267659120908115. PMID: 32397891
The impact of high frequency oscillatory ventilation on mortality in paediatric acute respiratory distress syndrome.
Wong JJ, Liu S, Dang H, Anantasit N, Phan PH, Phumeetham S, Qian S, Ong JSM, Gan CS, Chor YK, Samransamruajkit R, Loh TF, Feng M, Lee JH; Pediatric Acute & Critical care Medicine Asian Network (PACCMAN)
Crit Care 2020 Jan 31;24(1):31. doi: 10.1186/s13054-020-2741-x. PMID: 32005285Free PMC Article
Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with extracorporeal membrane oxygenation.
Rozencwajg S, Pilcher D, Combes A, Schmidt M
Crit Care 2016 Dec 5;20(1):392. doi: 10.1186/s13054-016-1568-y. PMID: 27919283Free PMC Article
Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials.
Alhazzani W, Alshahrani M, Jaeschke R, Forel JM, Papazian L, Sevransky J, Meade MO
Crit Care 2013 Mar 11;17(2):R43. doi: 10.1186/cc12557. PMID: 23497608Free PMC Article

Therapy

Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome.
Patel BM, Reilly JP, Bhalla AK, Smith LS, Khemani RG, Jones TK, Meyer NJ, Harhay MO, Yehya N
Am J Respir Crit Care Med 2024 Apr 1;209(7):871-878. doi: 10.1164/rccm.202310-1926OC. PMID: 38306669Free PMC Article
Corticosteroids treatment for pediatric acute respiratory syndrome: A critical review.
Al-Sofyani KA
Saudi Med J 2023 May;44(5):440-449. doi: 10.15537/smj.2023.44.5.20220672. PMID: 37182909Free PMC Article
Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials.
Alhazzani W, Alshahrani M, Jaeschke R, Forel JM, Papazian L, Sevransky J, Meade MO
Crit Care 2013 Mar 11;17(2):R43. doi: 10.1186/cc12557. PMID: 23497608Free PMC Article
Has high-frequency ventilation been inappropriately discarded in adult acute respiratory distress syndrome?
Herridge MS, Slutsky AS, Colditz GA
Crit Care Med 1998 Dec;26(12):2073-7. doi: 10.1097/00003246-199812000-00044. PMID: 9875923
Acute respiratory distress syndrome in children.
Beaufils F, Mercier JC, Farnoux C, Saizou C, Thébaud B
Curr Opin Pediatr 1997 Jun;9(3):207-12. doi: 10.1097/00008480-199706000-00003. PMID: 9229157

Prognosis

Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome.
Patel BM, Reilly JP, Bhalla AK, Smith LS, Khemani RG, Jones TK, Meyer NJ, Harhay MO, Yehya N
Am J Respir Crit Care Med 2024 Apr 1;209(7):871-878. doi: 10.1164/rccm.202310-1926OC. PMID: 38306669Free PMC Article
Understanding clinical and biological heterogeneity to advance precision medicine in paediatric acute respiratory distress syndrome.
Kneyber MCJ, Khemani RG, Bhalla A, Blokpoel RGT, Cruces P, Dahmer MK, Emeriaud G, Grunwell J, Ilia S, Katira BH, Lopez-Fernandez YM, Rajapreyar P, Sanchez-Pinto LN, Rimensberger PC
Lancet Respir Med 2023 Feb;11(2):197-212. Epub 2022 Dec 22 doi: 10.1016/S2213-2600(22)00483-0. PMID: 36566767Free PMC Article
Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with extracorporeal membrane oxygenation.
Rozencwajg S, Pilcher D, Combes A, Schmidt M
Crit Care 2016 Dec 5;20(1):392. doi: 10.1186/s13054-016-1568-y. PMID: 27919283Free PMC Article
Pulmonary specific ancillary treatment for pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference.
Tamburro RF, Kneyber MC; Pediatric Acute Lung Injury Consensus Conference Group
Pediatr Crit Care Med 2015 Jun;16(5 Suppl 1):S61-72. doi: 10.1097/PCC.0000000000000434. PMID: 26035366
Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the Pediatric Acute Lung Injury Consensus Conference.
Khemani RG, Smith LS, Zimmerman JJ, Erickson S; Pediatric Acute Lung Injury Consensus Conference Group
Pediatr Crit Care Med 2015 Jun;16(5 Suppl 1):S23-40. doi: 10.1097/PCC.0000000000000432. PMID: 26035358

Clinical prediction guides

Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome.
Patel BM, Reilly JP, Bhalla AK, Smith LS, Khemani RG, Jones TK, Meyer NJ, Harhay MO, Yehya N
Am J Respir Crit Care Med 2024 Apr 1;209(7):871-878. doi: 10.1164/rccm.202310-1926OC. PMID: 38306669Free PMC Article
Prediction of readiness to decannulation from venovenous extracorporeal membrane oxygenation.
Hartley EL, Sanderson B, Vasques F, Daly KJ, Lozinski M, Barrett NA, Camporota L
Perfusion 2020 May;35(1_suppl):57-64. doi: 10.1177/0267659120908115. PMID: 32397891
The impact of high frequency oscillatory ventilation on mortality in paediatric acute respiratory distress syndrome.
Wong JJ, Liu S, Dang H, Anantasit N, Phan PH, Phumeetham S, Qian S, Ong JSM, Gan CS, Chor YK, Samransamruajkit R, Loh TF, Feng M, Lee JH; Pediatric Acute & Critical care Medicine Asian Network (PACCMAN)
Crit Care 2020 Jan 31;24(1):31. doi: 10.1186/s13054-020-2741-x. PMID: 32005285Free PMC Article
Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with extracorporeal membrane oxygenation.
Rozencwajg S, Pilcher D, Combes A, Schmidt M
Crit Care 2016 Dec 5;20(1):392. doi: 10.1186/s13054-016-1568-y. PMID: 27919283Free PMC Article
High-frequency oscillatory ventilation in adult acute respiratory distress syndrome.
David M, Weiler N, Heinrichs W, Neumann M, Joost T, Markstaller K, Eberle B
Intensive Care Med 2003 Oct;29(10):1656-65. Epub 2003 Jul 25 doi: 10.1007/s00134-003-1897-6. PMID: 12897997

Recent systematic reviews

Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials.
Alhazzani W, Alshahrani M, Jaeschke R, Forel JM, Papazian L, Sevransky J, Meade MO
Crit Care 2013 Mar 11;17(2):R43. doi: 10.1186/cc12557. PMID: 23497608Free PMC Article
Extracorporeal membrane oxygenation in adult acute respiratory distress syndrome.
Park PK, Napolitano LM, Bartlett RH
Crit Care Clin 2011 Jul;27(3):627-46. doi: 10.1016/j.ccc.2011.05.009. PMID: 21742220

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